Article
Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.
Cancer research - 1 Dec 1997
Gonzalgo M L, Bender C M, You E H, Glendening J M, Flores J F, Walker G J, Hayward N K, Jones P A, Fountain J W
Abstract excerpt
Methylation of the 5' CpG island of the p16 tumor suppressor gene represents one possible mechanism for inactivation of this cell cycle regulatory gene that is also a melanoma predisposition locus. We have investigated the potential contribution of somatic silencing of the p16 gene by DNA methylation in 30 cases of sporadic cutaneous melanoma. The methylation status of the 5' CpG island of p16 was initially...
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