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Article

Inactivation of the p16INK4A gene by methylation is not a frequent event in sporadic ovarian carcinoma.

Oncology reports - 1 Jan 2000

Brown I, Milner B J, Rooney P H, Haites N E

Abstract excerpt

The p16INK4A tumour suppressor gene (p16) encodes for a cyclin-dependant kinase inhibitor which plays a role in the phosphorylation of the retinoblastoma protein (pRb) during regulation of the G1-S phase of the cell cycle. Loss of heterozygosity at 9p21, the chromosomal location of the p16 gene, has been reported in a broad range of tumours and this is usually indicative of the presence of a tumour suppressor...

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Share to CpG Islands
Share to DNA Methylation
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p16

Share to Ovarian Neoplasms

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 11605066
DOI: 10.3892/or.8.6.1359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of the p16INK4A gene by methylation is not a frequent event in sporadic ovarian carcinoma.PMID 11605066Read ↗

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