Article
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Nature medicine - 1 Jul 1995
Merlo A, Herman J G, Mao L, Lee D J, Gabrielson E, Burger P C, Baylin S B, Sidransky D
Abstract excerpt
Loss of heterozygosity on chromosome 9p21 is one of the most frequent genetic alterations identified in human cancer. The rate of point mutations of p16, a candidate suppressor gene of this area, is low in most primary tumours with allelic loss of 9p21. Monosomic cell lines with structurally unal...
Topics
- 5-Methylcytosine
- Alleles
- Azacitidine
- Base Sequence
- Brain Neoplasms
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Carrier Proteins
- Chromosomes, Human, Pair 9
- CpG Islands
- Cyclin-Dependent Kinase Inhibitor p16
- Cytosine
- DNA, Neoplasm
- Decitabine
- Gene Expression Regulation, Neoplastic