Article
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes, chromosomes & cancer - 1 Jun 1998
Walker G J, Flores J F, Glendening J M, Lin A H, Markl I D, Fountain J W
Abstract excerpt
The cyclin-dependent kinase inhibitor 2A (CDKN2A), or p16INK4a, gene on 9p21 is important in the genesis of both familial and sporadic melanoma. Homozygous deletions and intragenic mutations of this gene have been identified in both melanoma cell lines and uncultured tumors, although the frequenc...
Topics
- Carrier Proteins
- Cell Cycle Proteins
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Deletion
- Humans
- Melanoma
- Mutation
- Tumor Cells, Cultured
- Tumor Suppressor Proteins