Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression and localization of mutant p16 proteins in melanocytic lesions from familial melanoma patients.

Human pathology - 1 Jan 2004

Ghiorzo Paola, Villaggio Barbara, Sementa Angela Rita, Hansson Johan, Platz Anton, Nicoló Guido, Spina Bruno, Canepa Marco, Palmer Jane M, Hayward Nicholas K, Bianchi-Scarrà Giovanna

Abstract excerpt

Little is known about the correlation between the loss of p16 expression and tumor progression in familial melanoma; no systematic study has been conducted on p16 expression in melanocytic tumors from patients carrying germline CDKN2A mutations. We analyzed 98 early primary lesions from familial patients, previously tested for germline CDKN2A status, by quantitative immunohistochemistry using 3 p16 antibodies. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Genes, p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Image Processing, Computer-Assisted

Share to Melanocytes

Share to Melanoma

Share to Skin Neoplasms

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 14745721
DOI: 10.1016/j.humpath.2003.08.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression and localization of mutant p16 proteins in melanocytic lesions from familial melanoma patients.PMID 14745721Read ↗

p16INK4a expression is frequently decreased and associated with 9p21 loss of heterozygosity in sporadic melanomaSemantic proximity Read ↗

Loss of expression of thep16INK4/CDKN2 gene in cutaneous malignant melanoma correlates with tumor cell proliferation and invasive stageSemantic proximity Read ↗

Germline p16 mutations in familial melanomaSemantic proximity Read ↗

Melanoma development in relation to non-functional p16/INK4A protein and dysplastic naevus syndrome in Swedish melanoma kindreds.Semantic proximity Read ↗

Analysis of the p16 gene status of non-familial dysplastic nevus syndrome patients.Semantic proximity Read ↗

Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.Semantic proximity Read ↗

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma.Semantic proximity Read ↗

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.Semantic proximity Read ↗

Immunohistochemical detection of CDK4 and 9 16<sup>INK4</sup>proteins in cutaneous malignant melanomaSemantic proximity Read ↗

Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors.Semantic proximity Read ↗

Homozygous deletion of the p16INK4a and the p15INK4b tumour suppressor genes in a subset of human sporadic cutaneous malignant melanoma.Semantic proximity Read ↗

Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.