Article
Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanomas.
British journal of cancer - 1 Apr 1996
Maelandsmo G M, Flørenes V A, Hovig E, Oyjord T, Engebraaten O, Holm R, Børresen A L, Fodstad O
Abstract excerpt
Biopsies from 61 sporadic metastatic malignant melanomas and five melanoma cell lines were examined for homozygous deletions and mutations in the CDKN2 gene (p16). As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also screened for amplifications of the last two genes. Moreover, the transcript levels of the genes were determined and...
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