Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in the CDKN2A (p16INK4a) gene in microdissected sporadic primary melanomas.

International journal of cancer - 19 Jan 1998

Kumar R, Lundh Rozell B, Louhelainen J, Hemminki K

Abstract excerpt

The role of the CDKN2A (p16INK4a) gene in sporadic primary melanomas has remained unclear due to the inadequate number of mutational studies. In the present study, we analyzed the entire coding region of the CDKN2A gene in microdissected sporadic primary melanomas, for the presence of mutations and polymorphisms, using 2 independent methods of mutation detection, SSCP and CMC. We found 11 intragenic mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Melanoma
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Genetic

Share to Skin Neoplasms

Source

Identifiers

PMID: 9462707
DOI: 10.1002/(sici)1097-0215(19980119)75:2<193::aid-ijc5>3.0.co;2-p

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in the CDKN2A (p16INK4a) gene in microdissected sporadic primary melanomas.PMID 9462707Read ↗

Sporadic multiple primary melanoma cases: CDKN2A germline mutations with a founder effect.Semantic proximity Read ↗

CDKN2A mutations in multiple primary melanomas.Semantic proximity Read ↗

A single nucleotide polymorphism in the 3'untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare.Semantic proximity Read ↗

Role of the <i>CDKN2A</i> Locus in Patients With Multiple Primary MelanomasSemantic proximity Read ↗

Analysis of mutations in the p16/CDKN2A gene in sporadic and familial melanoma in the Polish population.Semantic proximity Read ↗

Genetic alterations of p16INK4a and p53 genes in sporadic dysplastic nevus.Semantic proximity Read ↗

CDKN2A germline mutations in individuals with cutaneous malignant melanoma.Semantic proximity Read ↗

Noncoding germline mutations in p16/CDKN2A in melanoma-prone families.Semantic proximity Read ↗

Rarity of CDK4 germline mutations in familial melanoma.Semantic proximity Read ↗

A search for CDKN2A/p16INK4a mutations in melanocytic nevi from patients with melanoma and spouse controls by use of laser-captured microdissection.Semantic proximity Read ↗

Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma.Semantic proximity Read ↗

CDKN2A (p16INK4A) somatic and germline mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.