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Article

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.

Oncogene - 14 Sept 2000

Silvany R E, Eliazer S, Wolff N C, Ilaria R L

Abstract excerpt

The chimeric gene EWS/FLI-1, the hallmark of the Ewing's sarcoma and primitive neuroectodermal tumor family, encodes a fusion protein with enhanced transcriptional activation properties and preserved recognition of canonical ETS binding sites. Although EWS/FLI-1 alters the expression of various genes, the precise mechanism by which EWS/FLI-1 acts as an oncogene remains to be defined. In this study we report that...

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PMID: 11002425
DOI: 10.1038/sj.onc.1203811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.PMID 11002425Read ↗

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.Semantic proximity Read ↗

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.Semantic proximity Read ↗

Identification of target genes in their native cellular context: an analysis of EWS/FLI in Ewing's sarcoma.Semantic proximity Read ↗

Targeting of EWS/FLI-1 by RNA interference attenuates the tumor phenotype of Ewing's sarcoma cells in vitro.Semantic proximity Read ↗

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation.Semantic proximity Read ↗

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.Semantic proximity Read ↗

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1.Semantic proximity Read ↗

MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.Semantic proximity Read ↗

Suppression of the Ewing's sarcoma phenotype by FLI1/ERF repressor hybrids.Semantic proximity Read ↗

The Insulin-like Growth Factor-I Receptor Is Required for EWS/FLI-1 Transformation of FibroblastsSemantic proximity Read ↗

Divergent Ewing's sarcoma EWS/ETS fusions confer a common tumorigenic phenotype on NIH3T3 cells.Semantic proximity Read ↗

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