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Article

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.

British journal of cancer - 13 Jan 2003

Chan D, Wilson T J, Xu D, Cowdery H E, Sanij E, Hertzog P J, Kola I

Abstract excerpt

Ewing's sarcoma is a childhood bone tumour with poor prognosis, most commonly associated with a t(11;22)(q24;q12) reciprocal translocation that fuses the EWS and FLI-1 genes, resulting in the production of an aberrant chimeric transcription factor EWS/FLI-1. To elucidate the mechanisms by which EWS/FLI-1 mediates transformation in mouse models, we have generated a murine Ews/Fli-1 fusion protein. We demonstrate...

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Identifiers

PMID: 12556973
DOI: 10.1038/sj.bjc.6600669
PMCID: PMC2376791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1.PMID 12556973Read ↗

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Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation.Semantic proximity Read ↗

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The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcomaSemantic proximity Read ↗

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Alteration of Mesodermal Cell Differentiation by EWS / FLI - 1 , the Oncogene Implicated in Ewing's SarcomaSemantic proximity Read ↗

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DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma.Semantic proximity Read ↗

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