Alteration of Mesodermal Cell Differentiation by EWS / FLI - 1 , the Oncogene Implicated in Ewing's Sarcoma

Abstract excerpt

The chimeric fusion gene EWS/FLI-1 is detected in most cases of Ewing's sarcoma (ES), the second most common malignant bone tumor of childhood. Although 80% of ES tumors develop in skeletal sites, the remainder can arise in almost any soft tissue location. The lineage of the cell developing the EWS/FLI-1 gene fusion has not been fully characterized but is generally considered to be of either mesenchymal or neural...

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