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Article

Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex.

Nucleic acids research - 1 Oct 1997

Deufel A, Hermann T, Kahmann R, Muskhelishvili G

Abstract excerpt

Efficient DNA inversion catalysed by the invertase Gin requires the cis-acting recombinational enhancer and the Escherichia coliFIS protein. Binding of FIS bends the enhancer DNA and, on a negatively supercoiled DNA inversion substrate, facilitates the formation of a synaptic complex with specific topology. Previous studies have indicated that FIS-independent Gin mutants can be isolated which have lost the...

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Identifiers

PMID: 9380505
DOI: 10.1093/nar/25.19.3832
PMCID: PMC146962

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex.PMID 9380505Read ↗

Analysis of strand exchange and DNA binding of enhancer-independent Gin recombinase mutants.Semantic proximity Read ↗

Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange.Semantic proximity Read ↗

Gin mutants that can be suppressed by a Fis-independent mutation.Semantic proximity Read ↗

Intrasubunit and intersubunit interactions controlling assembly of active synaptic complexes during Hin-catalyzed DNA recombination.Semantic proximity Read ↗

Role of Gin and FIS in site-specific recombination.Semantic proximity Read ↗

In vivo assay of protein-protein interactions in Hin-mediated DNA inversion.Semantic proximity Read ↗

Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity.Semantic proximity Read ↗

In vivo identification of intermediate stages of the DNA inversion reaction catalyzed by the Salmonella Hin recombinase.Semantic proximity Read ↗

The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion.Semantic proximity Read ↗

Mechanical constraints on Hin subunit rotation imposed by the Fis/enhancer system and DNA supercoiling during site-specific recombination.Semantic proximity Read ↗

DNA binding and bending are necessary but not sufficient for Fis-dependent activation of rrnB P1.Semantic proximity Read ↗

Alterations in the directionality of lambda site-specific recombination catalyzed by mutant integrases in vivo.Semantic proximity Read ↗

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