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Article

Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex.

Nucleic acids research - 1 Oct 1997

Deufel A, Hermann T, Kahmann R, Muskhelishvili G

Abstract excerpt

Efficient DNA inversion catalysed by the invertase Gin requires the cis-acting recombinational enhancer and the Escherichia coliFIS protein. Binding of FIS bends the enhancer DNA and, on a negatively supercoiled DNA inversion substrate, facilitates the formation of a synaptic complex with specific topology. Previous studies have indicated that FIS-independent Gin mutants can be isolated which have lost the...

Topics

Base Sequence
Binding Sites
Carrier Proteins
DNA Nucleotidyltransferases
DNA Primers
DNA, Bacterial
Enhancer Elements, Genetic
Escherichia coli
Escherichia coli Proteins
Factor For Inversion Stimulation Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Integration Host Factors

Mutagenesis, Site-Directed

Mutation

Recombination, Genetic

Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 9380505
DOI: 10.1093/nar/25.19.3832
PMCID: PMC146962

Provenance

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Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex.PMID 9380505Read ↗

Analysis of strand exchange and DNA binding of enhancer-independent Gin recombinase mutants.Semantic proximity Read ↗

Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange.Semantic proximity Read ↗

Gin mutants that can be suppressed by a Fis-independent mutation.Semantic proximity Read ↗

Intrasubunit and intersubunit interactions controlling assembly of active synaptic complexes during Hin-catalyzed DNA recombination.Semantic proximity Read ↗

Role of Gin and FIS in site-specific recombination.Semantic proximity Read ↗

In vivo assay of protein-protein interactions in Hin-mediated DNA inversion.Semantic proximity Read ↗

Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity.Semantic proximity Read ↗

In vivo identification of intermediate stages of the DNA inversion reaction catalyzed by the Salmonella Hin recombinase.Semantic proximity Read ↗

The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion.Semantic proximity Read ↗

Mechanical constraints on Hin subunit rotation imposed by the Fis/enhancer system and DNA supercoiling during site-specific recombination.Semantic proximity Read ↗

DNA binding and bending are necessary but not sufficient for Fis-dependent activation of rrnB P1.Semantic proximity Read ↗

Alterations in the directionality of lambda site-specific recombination catalyzed by mutant integrases in vivo.Semantic proximity Read ↗

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