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Article

Alterations in the directionality of lambda site-specific recombination catalyzed by mutant integrases in vivo.

Journal of molecular biology - 21 May 1999

Christ N, Dröge P

Abstract excerpt

Phage lambda integrative and excisive recombination normally proceeds by a pair of sequential strand exchanges. During the first exchange reaction, the "top" strand in each recombination site is cleaved, exchanged, and religated generating a Holliday junction intermediate. This intermediate DNA structure is resolved through a pair of reciprocal "bottom" strand exchanges, leading to recombinant products. The...

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Identifiers

PMID: 10329182
DOI: 10.1006/jmbi.1999.2730

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