Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange.

Abstract excerpt

The Gin recombinase of phage Mu selectively mediates DNA inversion between two inversely oriented recombination sites (gix) and requires the assistance of three accessory factors: negative supercoiling, an enhancer sequence, and the protein Fis. Deletion and fusion reactions are proscribed. Recombination by Gin is selective because it occurs only through a particular synaptic complex tailored for inversion. A...

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