Article
The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion.
Current biology : CB - 1 Feb 1996
Haykinson M J, Johnson L M, Soong J, Johnson R C
Abstract excerpt
BACKGROUND: Hin is a member of an extended family of site-specific recombinases--the DNA invertase/resolvase family--that catalyze inversion or deletion of DNA. DNA inversion by Hin occurs between two recombination sites and requires the regulatory protein Fis, which associates with a cis-acting...
Topics
- Binding Sites
- Carrier Proteins
- Catalysis
- Cholic Acids
- Chromosome Inversion
- DNA
- DNA Nucleotidyltransferases
- Detergents
- Disulfides
- Factor For Inversion Stimulation Protein
- Integration Host Factors
- Models, Molecular
- Mutation
- Protein Binding
- Recombination, Genetic
- Structure-Activity Relationship