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Article

DNA binding and bending are necessary but not sufficient for Fis-dependent activation of rrnB P1.

Journal of bacteriology - 1 Mar 1993

Gosink K K, Ross W, Leirmo S, Osuna R, Finkel S E, Johnson R C, Gourse R L

Abstract excerpt

The Escherichia coli Fis protein binds to three sites in the upstream activation region of the rrnB P1 promoter and enhances transcription 5- to 10-fold in vivo. In this report, we investigate the mechanism of Fis-dependent activation of transcription. We show that stimulation of rrnB P1 transcription by Fis can occur on linear DNA templates and does not require DNA upstream of the promoter-proximal Fis site I....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 8449867
DOI: 10.1128/jb.175.6.1580-1589.1993
PMCID: PMC203950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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DNA binding and bending are necessary but not sufficient for Fis-dependent activation of rrnB P1.PMID 8449867Read ↗

Structural analysis of the transcriptional activation region on Fis: crystal structures of six Fis mutants with different activation properties.Semantic proximity Read ↗

Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex.Semantic proximity Read ↗

Regulation of rRNA transcription is remarkably robust: FIS compensates for altered nucleoside triphosphate sensing by mutant RNA polymerases at Escherichia coli rrn P1 promoters.Semantic proximity Read ↗

Sequences upstream of the-35 hexamer of rrnB P1 affect promoter strength and upstream activation.Semantic proximity Read ↗

Transcriptional activation by protein-induced DNA bending: evidence for a DNA structural transmission model.Semantic proximity Read ↗

In vivo identification of intermediate stages of the DNA inversion reaction catalyzed by the Salmonella Hin recombinase.Semantic proximity Read ↗

Promoter protection by a transcription factor acting as a local topological homeostat.Semantic proximity Read ↗

FIS-dependent trans-activation of tRNA and rRNA operons of Escherichia coli.Semantic proximity Read ↗

The C-terminal domains of the RNA polymerase alpha subunits: contact site with Fis and localization during co-activation with CRP at the Escherichia coli proP P2 promoter.Semantic proximity Read ↗

Maximal transcriptional activation by the IHF protein of Escherichia coli depends on optimal DNA bending by the activator.Semantic proximity Read ↗

Spatial relationship of the Fis binding sites for Hin recombinational enhancer activity.Semantic proximity Read ↗

Localization of amino acids required for Fis to function as a class II transcriptional activator at the RpoS-dependent proP P2 promoter.Semantic proximity Read ↗

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