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Article

Mechanical constraints on Hin subunit rotation imposed by the Fis/enhancer system and DNA supercoiling during site-specific recombination.

Molecular cell - 26 Jun 2009

Dhar Gautam, Heiss John K, Johnson Reid C

Abstract excerpt

Hin, a member of the serine family of site-specific recombinases, regulates gene expression by inverting a DNA segment. DNA inversion requires assembly of an invertasome complex in which a recombinational enhancer DNA segment bound by the Fis protein associates with the Hin synaptic complex at the base of a supercoiled DNA branch. Each of the four Hin subunits becomes covalently joined to the cleaved DNA ends,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19560425
DOI: 10.1016/j.molcel.2009.05.020
PMCID: PMC2752211

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Source receipt: pubmed, retrieved 7 Sept 2026.

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