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Article

Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: the importance of maturation cocktails.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Jongmans Wim, Tiemessen Dorien M, van Vlodrop Iris J H, Mulders Peter F A, Oosterwijk Egbert

Abstract excerpt

The maturation state of (monocyte-derived) dendritic cells (DCs) determines the type of T-cell response. Currently, several maturation cocktails are used in clinical trials, most commonly a cocktail of TNF-alpha, PGE2, IL-1beta, and IL-6. The authors studied DC phenotype and functional ability to stimulate TH1 responses after maturation with different cocktails employing clinically approved agents. DCs were...

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Source

Identifiers

PMID: 16113604
DOI: 10.1097/01.cji.0000171290.78495.66

Genes

TNF
CCR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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