Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Probing the proximity of the core domain of an HIV-1 Tat fragment in a Tat-TAR complex by affinity cleaving.

Biochemistry - 14 Oct 1997

Huq I, Rana T M

Abstract excerpt

Transactivation of human immunodeficiency virus (HIV) gene expression depends upon the interaction of the viral regulatory protein Tat with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all mRNAs. We have used a site-directed RNA-cleaving strategy to determine the neighborhood of the core domain of a Tat fragment in the Tat-TAR complex. We synthesized a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Gene Products, tat
Share to HIV-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Protein Conformation

Share to RNA, Viral

Source

Identifiers

PMID: 9376365
DOI: 10.1021/bi971011g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Probing the proximity of the core domain of an HIV-1 Tat fragment in a Tat-TAR complex by affinity cleaving.PMID 9376365Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.Semantic proximity Read ↗

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.Semantic proximity Read ↗

A comparative binding study of modified bovine immunodeficiency virus TAR RNA against its TAT peptide.Semantic proximity Read ↗

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.Semantic proximity Read ↗

Interaction of human immunodeficiency virus type 1 Tat-derived peptides with TAR RNA.Semantic proximity Read ↗

Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylationSemantic proximity Read ↗

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.Semantic proximity Read ↗

The sequence and structure of the 3' arm of the first stem-loop of the human immunodeficiency virus type 2 trans-activation responsive region mediate Tat-2 transactivation.Semantic proximity Read ↗

Molecular basis of HIV-1 TAR RNA specific recognition by an acridine tat-antagonist.Semantic proximity Read ↗

Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition.Semantic proximity Read ↗

Enhanced binding of the TATA-binding protein to TATA boxes containing flanking cisplatin 1,2-cross-links.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.