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Article

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.

Nucleic acids research - 25 Nov 1991

Berkhout B, Jeang K T

Abstract excerpt

Trans-activation of HIV-1 by the Tat protein is mediated through a cis-acting element (TAR) in the viral RNA. In order to obtain further insight into the molecular interactions for trans-activation, a detailed mutational analysis of TAR RNA was carried out. TAR RNA forms a hairpin structure with important sequence elements in the single-stranded bulge- and loop-domains. We found that the sequence of the...

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Identifiers

PMID: 1956776
DOI: 10.1093/nar/19.22.6169
PMCID: PMC329115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.PMID 1956776Read ↗

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