Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.

doi:10.1093/nar/19.22.6169

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Article

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.

Nucleic acids research - 25 Nov 1991

Berkhout B, Jeang K T

Abstract excerpt

Trans-activation of HIV-1 by the Tat protein is mediated through a cis-acting element (TAR) in the viral RNA. In order to obtain further insight into the molecular interactions for trans-activation, a detailed mutational analysis of TAR RNA was carried out. TAR RNA forms a hairpin structure with...

Topics

Base Sequence
Gene Products, tat
HIV Long Terminal Repeat
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Plasmids
RNA, Viral
RNA-Binding Proteins
Transcriptional Activation

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