Article
Enhanced binding of the TATA-binding protein to TATA boxes containing flanking cisplatin 1,2-cross-links.
Biochemistry - 18 Jul 2000
Cohen S M, Jamieson E R, Lippard S J
Abstract excerpt
The TATA-binding protein (TBP) is essential for transcription initiation in eukaryotes. TBP recognizes and binds to the minor groove of a consensus sequence, TATAAA, known as the TATA box or TATA element. DNA binding is affected largely by hydrophobic contacts and through the intercalation of two sets of adjacent phenylalanine residues. The resultant duplex is sharply kinked, bending toward the major groove....
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