Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.

The Journal of biological chemistry - 3 Oct 2003

Kulinski Tadeusz, Olejniczak Mikolaj, Huthoff Hendrik, Bielecki Lukasz, Pachulska-Wieczorek Katarzyna, Das Atze T, Berkhout Ben, Adamiak Ryszard W

Abstract excerpt

The TAR hairpin of the HIV-1 RNA genome is indispensable for trans-activation of the viral promoter and virus replication. The TAR structure has been studied extensively, but most attention has been directed at the three-nucleotide bulge that constitutes the binding site of the viral Tat protein. In contrast, the conformational properties of the apical loop have remained elusive. We performed biochemical studies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Aminopurine
Share to HIV Long Terminal Repeat

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Luciferases

Share to Oligoribonucleotides

Share to RNA, Ribosomal

Share to RNA, Transfer

Share to Thermodynamics

Share to Ultraviolet Rays

Source

Identifiers

PMID: 12882959
DOI: 10.1074/jbc.M301939200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.PMID 12882959Read ↗

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.Semantic proximity Read ↗

Tertiary Element Interaction in HIV-1 TAR.Semantic proximity Read ↗

Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodelingSemantic proximity Read ↗

Structural requirements for trans activation of human immunodeficiency virus type 1 long terminal repeat-directed gene expression by tat: importance of base pairing, loop sequence, and bulges in the tat-responsive sequence.Semantic proximity Read ↗

Destabilization of the TAR hairpin leads to extension of the polyA hairpin and inhibition of HIV-1 polyadenylationSemantic proximity Read ↗

Structural and computational studies of HIV-1 RNASemantic proximity Read ↗

Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis.Semantic proximity Read ↗

Mutations in the TAR hairpin affect the equilibrium between alternative conformations of the HIV-1 leader RNA.Semantic proximity Read ↗

The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat ProteinSemantic proximity Read ↗

An Arg/Lys-rich core peptide mimics TRBP binding to the HIV-1 TAR RNA upper-stem/loop.Semantic proximity Read ↗

Opening of the TAR hairpin in the HIV-1 genome causes aberrant RNA dimerization and packaging.Semantic proximity Read ↗

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.