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Article

Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.

Chemistry & biology - 1 Mar 2005

Edwards Thomas E, Robinson Bruce H, Sigurdsson Snorri Th

Abstract excerpt

The Tat protein and the transactivation responsive (TAR) RNA form an essential complex in the HIV lifecycle, and mutations in the basic region of the Tat protein alter this RNA-protein molecular recognition. Here, EPR spectroscopy was used to identify amino acids, flanking an essential arginine of the Tat protein, which contribute to specific and rigid TAR-Tat complex formation by monitoring changes in the...

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Source

Identifiers

PMID: 15797217
DOI: 10.1016/j.chembiol.2005.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of amino acids that promote specific and rigid TAR RNA-tat protein complex formation.PMID 15797217Read ↗

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