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Article

In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP.

Journal of neuroscience research - 15 Oct 1997

Peyron F, Timsit S, Thomas J L, Kagawa T, Ikenaka K, Zalc B

Abstract excerpt

We analyzed by in situ hybridization the spatiotemporal expression of dm-20, myelin basic protein (MBP) and 2'-3' cyclic nucleotide phosphodiesterase (CNP) during embryonic and postnatal development of the normal mouse and two plp/dm-20 mutants: the jimpy mouse and a transgenic mouse overexpressi...

Topics

2',3'-Cyclic-Nucleotide Phosphodiesterases
Animals
Animals, Newborn
Apoproteins
Embryo, Mammalian
Embryonic and Fetal Development
Mice
Mice, Jimpy
Mice, Transgenic
Mutation
Myelin Basic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelin Proteolipid Protein

Nerve Tissue Proteins

RNA, Messenger

Reference Values

Source

Identifiers

PMID: 9373029
DOI: 10.1002/(SICI)1097-4547(19971015)50:2<190::AID-JNR8>3.0.CO;2-A

Genes

CNP
MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9373029-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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In situ expression of PLP/DM-20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP.PMID 9373029Read ↗

The early phenotype associated with the jimpy mutation of the proteolipid protein gene.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development.Semantic proximity Read ↗

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Temperature-dependent regulation of PLP/DM20 and CNP gene expression in two conditionally-immortalized jimpy oligodendrocyte cell lines.Semantic proximity Read ↗

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.Semantic proximity Read ↗

Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage.Semantic proximity Read ↗

Widespread expression of the peripheral myelin protein‐22 gene (<i>pmp</i>22) in neural and non‐neural tissues during murine developmentSemantic proximity Read ↗

Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.Semantic proximity Read ↗

Developmental expression of major myelin protein genes in the CNS of X-linked hypomyelinating mutant rumpshaker.Semantic proximity Read ↗

Normal temporal and spatial distribution of oligodendrocyte progenitors in the myelin-deficient (md) rat.Semantic proximity Read ↗

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