Article
Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.
Journal of neurochemistry - 1 Jan 1991
Macklin W B, Gardinier M V, Obeso Z O, King K D, Wight P A
Abstract excerpt
The mouse myelin proteolipid protein (PLP) gene has been studied in normal and jimpymsd mice. Potential upstream regulatory regions of the normal gene have been cloned and mapped, but when these regions were studied in jimpymsd mice by Southern blots, no alterations were observed, relative to the normal gene. To assess whether the low ratio of PLP to DM20 proteins in this mutant reflected an altered PLP/DM20...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Exons
- Gene Expression
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Myelin Proteins