Article
Normal temporal and spatial distribution of oligodendrocyte progenitors in the myelin-deficient (md) rat.
Journal of neuroscience research - 1 Feb 1997
Pringle N P, Nadon N L, Rhode D M, Richardson W D, Duncan I D
Abstract excerpt
A point mutation in exon 3 of the proteolipid protein (PLP) gene of the myelin-deficient (md) rat leads to a failure of oligodendrocyte maturation and early death of oligodendrocytes, resulting in dysmyelination. It has been suggested that an alternative-splice isoform of PLP, known as DM-20, mig...
Topics
- Animals
- Animals, Newborn
- Cell Count
- Central Nervous System
- Female
- Genotype
- Heterozygote
- In Situ Hybridization
- Male
- Myelin Proteolipid Protein
- Oligodendroglia
- Point Mutation
- Polymerase Chain Reaction
- Pregnancy
- RNA, Messenger
- Rats
- Rats, Mutant Strains
- Rats, Wistar