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Article

Temperature-dependent regulation of PLP/DM20 and CNP gene expression in two conditionally-immortalized jimpy oligodendrocyte cell lines.

Neurochemical research - 1 Apr 1997

Bongarzone E R, Foster L M, Byravan S, Schonmann V, Campagnoni A T

Abstract excerpt

We conditionally immortalized jimpy primary oligodendrocytes (ODCs) with the temperature-sensitive SV40 large T antigen. Two cell lines (clones JP1.1 and JP1.2) were generated that expressed a number of ODC markers. Both jimpy cell lines expressed DM20 mRNAs at the proliferative temperature of 34...

Topics

2',3'-Cyclic-Nucleotide Phosphodiesterases
Animals
Antigens, Polyomavirus Transforming
Cell Line, Transformed
Female
Gene Expression Regulation
Immunohistochemistry
Male
Mice
Mice, Jimpy
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelin Proteolipid Protein

Nerve Tissue Proteins

Oligodendroglia

Sphingolipids

Temperature

Source

Identifiers

PMID: 9130245
DOI: 10.1023/a:1027339222720

Genes

CNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9130245-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Temperature-dependent regulation of PLP/DM20 and CNP gene expression in two conditionally-immortalized jimpy oligodendrocyte cell lines.PMID 9130245Read ↗

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

The early phenotype associated with the jimpy mutation of the proteolipid protein gene.Semantic proximity Read ↗

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