Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.

Journal of neurobiology - 1 Feb 1996

Knapp P E, Benjamins J A, Skoff R P

Abstract excerpt

Proteolipid protein (PLP) is a major structural component of central nervous system (CNS) myelin. Evidence exists that PLP or the related splice variant DM-20 protein may also play a role in early development of oligodendrocytes (OLs), the cells that form CNS myelin. There are several naturally occurring mutations of the PLP gene that have been used to study the roles of PLP both in myelination and in OL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Immunohistochemistry
Share to Lipoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Protein Biosynthesis

Source

Identifiers

PMID: 8821173
DOI: 10.1002/(SICI)1097-4695(199602)29:2<138::AID-NEU2>3.0.CO;2-B

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.PMID 8821173Read ↗

The early phenotype associated with the jimpy mutation of the proteolipid protein gene.Semantic proximity Read ↗

Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.Semantic proximity Read ↗

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Evidence that CNS hypomyelination does not cause death of jimpy-msd mutant mice.Semantic proximity Read ↗

Oligodendrocyte development and differentiation in the rumpshaker mutation.Semantic proximity Read ↗

Developmental expression of major myelin protein genes in the CNS of X-linked hypomyelinating mutant rumpshaker.Semantic proximity Read ↗

Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.Semantic proximity Read ↗

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.Semantic proximity Read ↗

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.Semantic proximity Read ↗

Glial transplants: an in vivo analysis of extrinsic and intrinsic determinants of dysmyelination in genetic variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.