Article
A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.
Journal of neurochemistry - 1 Sept 1994
Nadon N L, Arnheiter H, Hudson L D
Abstract excerpt
Mutations in the myelin proteolipid protein (PLP) gene, such as that found in the jimpy mouse, result in an abnormal structure of the myelin, severe dysmyelination, and a reduction in the number of mature oligodendrocytes. To examine the functions of the two alternatively spliced isoforms of prot...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Blotting, Northern
- Gene Expression
- Mice
- Mice, Jimpy
- Mice, Transgenic
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Myelin Proteins
- Myelin Proteolipid Protein
- Myelin Sheath
- Phenotype
- RNA, Messenger