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Article

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.

Journal of neurochemistry - 1 Sept 1994

Nadon N L, Arnheiter H, Hudson L D

Abstract excerpt

Mutations in the myelin proteolipid protein (PLP) gene, such as that found in the jimpy mouse, result in an abnormal structure of the myelin, severe dysmyelination, and a reduction in the number of mature oligodendrocytes. To examine the functions of the two alternatively spliced isoforms of proteolipid protein, transgenic mice were generated that express either PLP or DM20 cDNAs placed under control of the PLP...

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PMID: 7519661
DOI: 10.1046/j.1471-4159.1994.63030822.x

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A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.PMID 7519661Read ↗

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.Semantic proximity Read ↗

Modification of Schwann cell phenotype with Plp transgenes: evidence that the PLP and DM20 isoproteins are targeted to different cellular domains.Semantic proximity Read ↗

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.Semantic proximity Read ↗

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.Semantic proximity Read ↗

Current concepts of PLP and its role in the nervous system.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Mutations in the myelin proteolipid protein gene alter oligodendrocyte gene expression in jimpy and jimpymsd mice.Semantic proximity Read ↗

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.Semantic proximity Read ↗

Myelination in the absence of galactolipids and proteolipid proteins.Semantic proximity Read ↗

Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms.Semantic proximity Read ↗

Genetic dissection of oligodendroglial and neuronal<i>Plp1</i>function in a novel mouse model of spastic paraplegia type 2Semantic proximity Read ↗

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