Article
Separate proteolipid protein/DM20 enhancers serve different lineages and stages of development.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jul 2008
Tuason Maria Clarita, Rastikerdar Ali, Kuhlmann Tanja, Goujet-Zalc Cécile, Zalc Bernard, Dib Samar, Friedman Hana, Peterson Alan
Abstract excerpt
The gene encoding DM20 emerged in cartilaginous fish, descending from a bilaterian ancestor of the M6 proteolipid gene family. Its proteolipid protein (PLP) isoform appeared in amphibians, contains an additional 35 amino acids, and, in the mammalian CNS, is the dominant myelin protein in which it confers an essential neuroprotective function. During development, the DM20 isoform is prominent in a number of...
Topics
- Animals
- Cell Differentiation
- Cell Lineage
- Embryonic Stem Cells
- Enhancer Elements, Genetic
- Evolution, Molecular
- Female
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Hypoxanthine Phosphoribosyltransferase
- Male
- Mice