Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.

doi:10.1111/j.1750-3639.1995.tb00604.x

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Article

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.

Brain pathology (Zurich, Switzerland) - 1 Jul 1995

Griffiths I R, Schneider A, Anderson J, Nave K A

Abstract excerpt

The X chromosome-linked PLP/DM-20 gene is the CNS myelin gene most frequently associated with mutations, resulting in dysmyelination in several species including man (Pelizaeus-Merzbacher disease, X-linked Spastic Paraplegia). The pathology of most PLP gene mutations is characterized by hypomyeli...

Topics

Animals
Demyelinating Diseases
Disease Models, Animal
Genome
Humans
Mice
Mice, Transgenic
Mutation
Myelin Proteolipid Protein
Peripheral Nervous System
Phenotype

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