Article
Novel isoforms of mouse myelin basic protein predominantly expressed in embryonic stage.
Journal of neurochemistry - 1 Apr 1993
Nakajima K, Ikenaka K, Kagawa T, Aruga J, Nakao J, Nakahira K, Shiota C, Kim S U, Mikoshiba K
Abstract excerpt
Myelin basic protein (MBP), a major protein of myelin, is thought to play an important role in myelination, which occurs postnatally in mouse. Here we report that the MBP gene is expressed from the 12th embryonic day in mouse brain and that most of the predominant embryonic isoforms are not those reported previously. These isoforms have a deletion of a sequence encoded by exon 5 from the well-known isoforms....
Topics
- Animals
- Base Sequence
- Brain
- Cloning, Molecular
- Demyelinating Diseases
- Exons
- Galactosylceramides
- Gene Expression
- Male
- Mice
- Mice, Inbred ICR
- Mice, Neurologic Mutants