Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High incidence of thymic epithelial tumors in E2F2 transgenic mice.

The Journal of biological chemistry - 12 Mar 2004

Scheijen Blanca, Bronk Marieke, van der Meer Tiffany, De Jong Daphne, Bernards René

Abstract excerpt

In virtually all human tumors, genetic and epigenetic alterations have been found which affect the INK4/-CYCLIN D/RB pathway, which regulates cell cycle entry and exit in normal cells. E2F transcription factors are important downstream components of this pathway, which act by controlling the expression of genes involved in DNA replication and cell cycle progression. To determine whether E2F2 deregulation promotes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to Blotting, Southern
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperplasia

Share to Neoplasms, Glandular and Epithelial

Share to Thymoma

Share to Thyroid Neoplasms

Share to Transgenes

Source

Identifiers

PMID: 14684733
DOI: 10.1074/jbc.M313682200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High incidence of thymic epithelial tumors in E2F2 transgenic mice.PMID 14684733Read ↗

A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.Semantic proximity Read ↗

Human thymoma-associated mutation of the GTF2I transcription factor impairs thymic epithelial progenitor differentiation in mice.Semantic proximity Read ↗

E2F2 suppresses Myc‐induced proliferation and tumorigenesisSemantic proximity Read ↗

High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Semantic proximity Read ↗

Deciphering the biology of thymic epithelial tumorsSemantic proximity Read ↗

Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation.Semantic proximity Read ↗

An Analysis of T Cell Intrinsic Roles of E2A by Conditional Gene Disruption in the ThymusSemantic proximity Read ↗

E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Semantic proximity Read ↗

Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CISSemantic proximity Read ↗

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell LymphomasSemantic proximity Read ↗

Proviral activation of the tumor suppressor E2a contributes to T cell lymphomagenesis in EmuMyc transgenic mice.Semantic proximity Read ↗

Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin ESemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.