Article
Genetic and epigenetic alterations in normal tissues have differential impacts on cancer risk among tissues
22 Jan 2018
Abstract excerpt
Genetic and epigenetic alterations are both involved in carcinogenesis, and their low-level accumulation in normal tissues constitutes cancer risk. However, their relative importance has never been examined, as measurement of low-level mutations has been difficult. Here, we measured low-level accumulations of genetic and epigenetic alterations in normal tissues with low, intermediate, and high cancer risk and...
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