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Article

Extremely high Tp53 mutation load in esophageal squamous cell carcinoma in Golestan Province, Iran.

PloS one - 1 Jan 2011

Abedi-Ardekani Behnoush, Kamangar Farin, Sotoudeh Masoud, Villar Stephanie, Islami Farhad, Aghcheli Karim, Nasrollahzadeh Dariush, Taghavi Noushin, Dawsey Sanford M, Abnet Christian C, Hewitt Stephen M, Fahimi Saman, Saidi Farrokh, Brennan Paul, Boffetta Paolo, Malekzadeh Reza, Hainaut Pierre

Abstract excerpt

BACKGROUND: Golestan Province in northeastern Iran has one of the highest incidences of esophageal squamous cell carcinoma (ESCC) in the world with rates over 50 per 100,000 person-years in both sexes. We have analyzed TP53 mutation patterns in tumors from this high-risk geographic area in search of clues to the mutagenic processes involved in causing ESCC. METHODOLOGY/PRINCIPAL FINDINGS: Biopsies of 119...

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Identifiers

PMID: 22216294
DOI: 10.1371/journal.pone.0029488
PMCID: PMC3246475

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Source receipt: pubmed, retrieved 7 Sept 2026.

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