Article
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone.
Nature - 6 Nov 1997
Yamauchi T, Ueki K, Tobe K, Tamemoto H, Sekine N, Wada M, Honjo M, Takahashi M, Takahashi T, Hirai H, Tushima T, Akanuma Y, Fujita T, Komuro I, Yazaki Y, Kadowaki T
Abstract excerpt
When growth hormone binds to its receptor, which belongs to the cytokine receptor superfamily, it activates the Janus kinase Jak2 which has tyrosine-kinase activity and initiates an activation of several key intracellular proteins (for example, mitogen-activated protein (MAP) kinases) that eventu...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- CHO Cells
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cricetinae
- Cytokines
- Enzyme Activation
- ErbB Receptors
- GRB2 Adaptor Protein
- Gene Expression Regulation
- Genes, fos
- Growth Hormone
- Humans