Article
Janus kinase 2 determinants for growth hormone receptor association, surface assembly, and signaling.
Molecular endocrinology (Baltimore, Md.) - 1 Nov 2003
He Kai, Wang Xiangdong, Jiang Jing, Guan Ran, Bernstein Kenneth E, Sayeski Peter P, Frank Stuart J
Abstract excerpt
GH signaling depends on functional interaction of the GH receptor (GHR) and the cytoplasmic tyrosine kinase, Janus kinase 2 (JAK2), which possesses a C-terminal kinase domain, a catalytically inactive pseudokinase domain just N-terminal to the kinase domain, and an N-terminal half shown by us and others to harbor elements for GHR association. Computational analyses indicate that JAKs contain in their N termini (...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.