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Article

Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor.

The Journal of biological chemistry - 16 Jun 1995

Frank S J, Yi W, Zhao Y, Goldsmith J F, Gilliland G, Jiang J, Sakai I, Kraft A S

Abstract excerpt

Growth hormone (GH) treatment of cells promotes activation of JAK2, a GH receptor (GHR)-associated tyrosine kinase. We now explore JAK2 regions required for GHR-induced signaling. Wild-type (WT) JAK2 and JAK2 molecules with deletions of the amino terminus (JAK2ATD), carboxyl terminus (JAK2CTD), or kinase-like domain (JAK2PKD) were each transiently coexpressed in COS-7 cells with the rabbit GHR. The following...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7540178
DOI: 10.1074/jbc.270.24.14776

Genes

JAK2
GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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