Article
Regions of the JAK2 tyrosine kinase required for coupling to the growth hormone receptor.
The Journal of biological chemistry - 16 Jun 1995
Frank S J, Yi W, Zhao Y, Goldsmith J F, Gilliland G, Jiang J, Sakai I, Kraft A S
Abstract excerpt
Growth hormone (GH) treatment of cells promotes activation of JAK2, a GH receptor (GHR)-associated tyrosine kinase. We now explore JAK2 regions required for GHR-induced signaling. Wild-type (WT) JAK2 and JAK2 molecules with deletions of the amino terminus (JAK2ATD), carboxyl terminus (JAK2CTD), o...
Topics
- Amino Acid Sequence
- Animals
- Cell Line
- Epitopes
- Genes, fos
- Janus Kinase 2
- Luciferases
- Mice
- Molecular Sequence Data
- Mutation
- Precipitin Tests
- Protein Binding