Article
A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.
The Journal of biological chemistry - 18 Mar 2005
Ferrand Audrey, Kowalski-Chauvel Aline, Bertrand Claudine, Escrieut Chantal, Mathieu Anne, Portolan Ghislaine, Pradayrol Lucien, Fourmy Daniel, Dufresne Marlene, Seva Catherine
Abstract excerpt
To date very few G protein-coupled receptors (GPCRs) have been shown to be connected to the Janus kinase (JAK)/STAT pathway. Thus our understanding of the mechanisms involved in the activation of this signaling pathway by GPCRs remains limited. In addition, little is known about the role of the JAK pathway in the physiological or pathophysiological functions of GPCRs. Here, we described a new mechanism of JAK...
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