Article
An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway.
The Journal of biological chemistry - 25 Aug 1995
Ueno H, Hirano N, Kozutsumi H, Sasaki K, Tanaka T, Yazaki Y, Hirai H
Abstract excerpt
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. Previously we cloned the full-length cDNA of human LTK, but no ligands have so far been identified, and hence, very little is known about the physiological role of LTK. To analyze the function of the LTK kinase, we constructed chimeric receptors composed of...
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