Article
An epidermal growth factor receptor-leukocyte tyrosine kinase chimeric receptor generates ligand-dependent growth signals through the Ras signaling pathway.
The Journal of biological chemistry - 25 Aug 1995
Ueno H, Hirano N, Kozutsumi H, Sasaki K, Tanaka T, Yazaki Y, Hirai H
Abstract excerpt
Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. Previously we cloned the full-length cDNA of human LTK, but no ligands have so far been identified, and hence, very little is known about th...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Base Sequence
- Cell Line
- DNA Primers
- DNA, Complementary
- ErbB Receptors
- GRB2 Adaptor Protein
- Gene Expression
- Humans
- Ligands
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Phosphorylation