Article
Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.
Endocrinology - 1 Oct 1994
Sotiropoulos A, Perrot-Applanat M, Dinerstein H, Pallier A, Postel-Vinay M C, Finidori J, Kelly P A
Abstract excerpt
The GH receptor (GHR) is a member of the cytokine/hematopoietic growth factor family, and protein tyrosine phosphorylation has been implicated in the signaling cascade of these receptors. It was recently shown that the tyrosine kinase JAK2 is associated with the GHR. GH induces the activation of JAK2, which phosphorylates itself and the receptor. Mitogen-activated protein (MAP) kinase activation and...
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