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Article

Role of HER receptors family in development and differentiation

23 Jan 2004

Abstract excerpt

Members of the epidermal growth factor receptor family of receptor tyrosine kinases play a critical role in both development and oncogenesis. The latter is suggested by the frequent overexpression of HER-2, EGFR, and HER-3 in some human carcinomas, primarily breast and squamous cancer. The biological activities of the EGFR family are exerted through various ligand-receptor and receptor-receptor interactions. One...

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PMID: 15254961
DOI: 10.1002/jcp.20007

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