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Article

Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms.

The American journal of physiology - 1 Oct 1997

Li Calzi S, Choice C V, Najjar S M

Abstract excerpt

The insulin receptor is expressed as two variably spliced isoforms that differ by the absence (isoform A) or presence (isoform B) of a 12-amino acid sequence encoded by exon 11 at the carboxy terminus of the alpha-subunit. Coexpression of the A isoform and pp120, a substrate of the insulin receptor tyrosine kinase, in NIH 3T3 fibroblasts increased receptor A-mediated insulin endocytosis and degradation by two- to...

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PMID: 9357811
DOI: 10.1152/ajpendo.1997.273.4.E801

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