Article
Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.
Molecular endocrinology (Baltimore, Md.) - 1 May 1991
McClain D A
Abstract excerpt
The human insulin receptor (hIR) is expressed in two variant forms that are generated by tissue-specific alternative splicing of the 11th exon of the IR gene. This leads to receptors that differ in their affinities for insulin based on the absence (hIR-A) or presence (hIR-B) of a 12-amino acid insert near the C-terminus of the alpha-subunit. To explore further the functional significance of the difference in...
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