Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.

doi:10.1210/mend-5-5-734

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Article

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.

Molecular endocrinology (Baltimore, Md.) - 1 May 1991

McClain D A

Abstract excerpt

The human insulin receptor (hIR) is expressed in two variant forms that are generated by tissue-specific alternative splicing of the 11th exon of the IR gene. This leads to receptors that differ in their affinities for insulin based on the absence (hIR-A) or presence (hIR-B) of a 12-amino acid in...

Topics

Animals
Clone Cells
Down-Regulation
Endocytosis
Genetic Variation
Humans
Insulin
Phosphorylation
RNA Splicing
RNA, Messenger
Rats
Receptor, Insulin

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