Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

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Article

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

The Journal of biological chemistry - 25 Sept 1990

Backer J M, Kahn C R, Cahill D A, Ullrich A, White M F

Abstract excerpt

The juxtamembrane region of the insulin receptor (IR) beta-subunit contains an unphosphorylated tyrosyl residue (Tyr960) that is essential for insulin-stimulated tyrosyl phosphorylation of some endogenous substrates and certain biological responses (White, M.F., Livingston, J.N., Backer, J.M., La...

Topics

Amino Acid Sequence
Animals
Cell Line
Cell Membrane
Humans
Insulin
Kinetics
Macromolecular Substances
Molecular Sequence Data
Mutation
Receptor, Insulin
Recombinant Proteins
Transfection

Source

Open in PubMed

Identifiers

PMID: 2204623

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2204623-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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