Article
Internalization of the constitutively active arginine 1152-->glutamine insulin receptor occurs independently of insulin at an accelerated rate.
The Journal of biological chemistry - 10 Jun 1994
Formisano P, DeNovellis G, Miele C, Tripodi F, Caruso M, Palumbo G, Beguinot L, Beguinot F
Abstract excerpt
Signals controlling the insulin receptor endocytotic pathway have been investigated using the R1152Q insulin receptor mutant (M). This mutant receptor exhibits high levels of insulin-independent kinase activity, impaired autophosphorylation, and lack of an insulin stimulatory effect on both auto-...
Topics
- 2,4-Dinitrophenol
- 3T3 Cells
- Animals
- Arginine
- Dinitrophenols
- Down-Regulation
- Endocytosis
- Glutamine
- Insulin
- Mice
- Mutation
- Phosphorylation
- Receptor Protein-Tyrosine Kinases
- Receptor, Insulin
- Signal Transduction
- Transfection
- Tromethamine