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Insulin receptor alternative splicing is regulated by insulin signaling and modulates beta cell survival

16 Aug 2016

Abstract excerpt

Type 2 Diabetes (T2DM) affects more than 300 million people worldwide. One of the hallmarks of T2DM is peripheral insulin resistance, in part due to unproductive insulin signaling through the insulin receptor. The insulin receptor (INSR) exists as two isoforms, INSR-A and INSR-B, which results from skipping or inclusion of exon 11 respectively. What determines the relative abundance of the different insulin...

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PMID: 27526875
DOI: 10.1038/srep31222

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