Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.

The Journal of biological chemistry - 6 Dec 2002

Whittaker Jonathan, Sørensen Heidi, Gadsbøll Vibeke L, Hinrichsen Jane

Abstract excerpt

The human insulin receptor is expressed as two isoforms that are generated by alternate splicing of its mRNA; the B isoform has 12 additional amino acids (718-729) encoded by exon 11 of the gene. The isoforms have been reported to have different ligand binding properties. To further characterize their insulin binding properties, we have performed structure-directed alanine-scanning mutagenesis of a major insulin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Insulin

Share to Oligonucleotides

Share to Phenylalanine

Share to Receptor, Insulin

Share to Valine

Source

Identifiers

PMID: 12270939
DOI: 10.1074/jbc.M208371200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.PMID 12270939Read ↗

Characterization of the functional insulin binding epitopes of the full-length insulin receptor.Semantic proximity Read ↗

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.Semantic proximity Read ↗

IGF1 and IGF2 specificities to the two insulin receptor isoforms are determined by insulin receptor amino acid 718Semantic proximity Read ↗

Alanine scanning mutagenesis of insulin.Semantic proximity Read ↗

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.Semantic proximity Read ↗

Two mutations in a conserved structural motif in the insulin receptor inhibit normal folding and intracellular transport of the receptor.Semantic proximity Read ↗

Converting Insulin-like Growth Factors 1 and 2 into High-Affinity Ligands for Insulin Receptor Isoform A by the Introduction of an Evolutionarily Divergent Mutation.Semantic proximity Read ↗

Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis.Semantic proximity Read ↗

The Insulin Receptor Isoform Exon 11- (IR-A) in Cancer and Other Diseases: A ReviewSemantic proximity Read ↗

Four new monomeric insulins obtained by alanine scanning the dimer-forming surface of the insulin molecule.Semantic proximity Read ↗

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex.Semantic proximity Read ↗

Differential effect of pp120 on insulin endocytosis by two variant insulin receptor isoforms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.