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Article

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors.

Journal of endocrinological investigation - 1 Nov 2003

Hamel F G, Fawcett J, Andersen C I, Berhanu P, Bennett R G, Duckworth W C

Abstract excerpt

The mechanism by which insulin decreases protein degradation is unknown. We examined insulin binding and degradation (125I[A14]insulin) and protein degradation (3H-leucine labeling) in Chinese hamster ovary (CHO) cells transfected with wild-type (WI) and mutant human insulin receptors. The deltaExon-16 mutant is missing the juxtamembrane domain that mediates endocytosis. The delta343 mutant receptor lacks the...

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Identifiers

PMID: 15008246
DOI: 10.1007/BF03345255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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