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Article

Mismatch repair defects and O6-methylguanine-DNA methyltransferase expression in acquired resistance to methylating agents in human cells.

The Journal of biological chemistry - 7 Nov 1997

Hampson R, Humbert O, Macpherson P, Aquilina G, Karran P

Abstract excerpt

Fifteen variants with >/=30-fold resistance to N-methyl-N-nitrosourea were isolated from the Burkitt's lymphoma Raji cell line. Eight had received a single treatment with a highly cytotoxic dose. The remainder, including the previously described RajiF12 cell line, arose following multiple exposur...

Topics

Blotting, Western
DNA
DNA Methylation
DNA Repair
Drug Resistance
Humans
Methylnitrosourea
Microsatellite Repeats
Mutagens
O(6)-Methylguanine-DNA Methyltransferase
Phenotype
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9353325
DOI: 10.1074/jbc.272.45.28596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9353325-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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