Article
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
The Journal of biological chemistry - 5 Oct 1993
Fritz G, Dosch J, Thielmann H W, Kaina B
Abstract excerpt
Methylating agents are widely distributed environmental mutagens. To identify mechanisms that protect cells against the toxic effects of methylating compounds Chinese hamster ovary (CHO) cells were transfected with human DNA and selected for resistance to methylating agents. From methylation-resistant transfectants, human DNA was cloned that conferred methylation resistance to CHO cells. A human cDNA was isolated...
Topics
- Amino Acid Sequence
- Animals
- Blood
- CHO Cells
- Cloning, Molecular
- Cricetinae
- DNA
- DNA Repair
- Drug Resistance
- HeLa Cells
- Humans
- Methylation
- Methylnitronitrosoguanidine
- Methylnitrosourea
- Molecular Sequence Data